doi:10.2147/TACG.S35301 - Free text at pubmed - Pubmed citation Pathogenesis of coronary artery disease: focus on genetic risk factors and identification of genetic variants. Sayols-Baixeras S, Lluís-Ganella C, Lucas G et-al. CT and MRI of coronary artery disease: evidence-based review. Noninvasive coronary artery imaging: magnetic resonance angiography and multidetector computed tomography angiography: a scientific statement from the american heart association committee on cardiovascular imaging and intervention of the council on cardiovascular radiology and intervention, and the councils on clinical cardiology and cardiovascular disease in the young. Schoepf UJ, Becker CR, Ohnesorge BM et-al. Pathophysiology of coronary artery disease. Pathophysiology and investigation of coronary artery disease. Coronary Artery Disease - Reporting and Data System (CAD-RADS).ACC/AHA classification of coronary lesions.The recently proposed SCCT grading scale for stenosis severity assesses the degree of luminal diameter stenosis 6: In a post-hoc analysis of prospective acquired data, a cutoff value > -70 HU of the perivascular fat attenuation index (FAI) around the proximal right coronary artery was found to be predictive of increased all-cause mortality 10. Haemodynamically-significant stenoses are those >70% for all coronary arteries, except the left main coronary artery where >50% stenosis is considered significant 7. patients with technically limited images from echocardiography or MRI.evaluation of coronary artery anatomy and bypass grafts.acute chest pain in patients with a low-to-intermediate pretest probability of coronary artery disease.There are several appropriate clinical indications for the performance of coronary CTA 8: Coronary angiography has been the mainstay for many years, but in certain patient groups is being replaced by non-invasive imaging such as coronary CT angiography (cCTA). There are a variety of techniques to image coronary artery disease including both anatomical and functional modalities. modifiable: hypercholesterolemia, left ventricular hypertrophy, obesity, hypertension, diabetes, sedentary lifestyle, smoking, alcohol 1.non-modifiable: family history, age, male sex 1.Thrombus formation after plaque disruption can lead to acute coronary syndrome 1,2. A stenosis of >50% of diameter or >75% cross-section diameter reduction can lead to angina. PathologyĬoronary artery disease is primarily due to atherosclerosis, an inflammatory process that leads to atheroma development and remodeling/stenosis of the coronary arteries.
CAD may also present with heart failure or sudden cardiac death. When severe enough it can cause angina or an acute coronary syndrome including myocardial infarction.
Coronary artery disease is asymptomatic in most of the population.